Themes of Research:
Microdomain organisation of MHC class II molecules
MHC class II mediated signaling
Regulation of survival of Antigen Presenting Cells
Group members
Dr N. Setterblad, Dr E. Assier, Dr A. Delaguillaumie, Mr. S. Bécart
Recent Publications:
1.
Bertho N, Blancheteau V, Setterblad N, Laupeze B, Drénou B, Amiot L,
Charron D, Fauchet R, Mooney N (2002). MHC class II mediated apoptosis of
mature dendritic cells proceeds by activation of the Protein Kinase C-d iso-enzyme.
Int. Imm. 14:1-8
2. Baumgartner M, Angelisova P, Setterblad N, Mooney N, Werling D, Horejsi
V, Langsley G.(2002) Constitutive exclusion of Csk from Hck-positive membrane
microdomains permits Src kinase-dependent proliferation of Theileria-transformed
B-lymphocytes. Blood.101:1874-81
3. Bécart S., Setterblad N, Ostrand-Rosenberg S, Ono S.J., Charron
D and Mooney N (2003) Intracytoplasmic domains of MHC class II molecules are
essential for lipid raft-dependent signalling. J. Cell
Science, 116:2565-75
4. Setterblad N, Roucard C, Bocaccio C, Abastado JP, Charron D and Mooney
N (2003) Composition of MHC class II-enriched lipid microdomains is modified
during maturation of primary dendritic cells. J. Leukocyte
Biology , 74:40-48.
5. Nagy Z and Mooney N (2003). A novel, alternative pathway of apoptosis triggered
through class II major histocompatibility complex molecules. J.
of Mol. Med. (In
Press)
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