Coordinator
Professor A M Dickinson BSc PhD Head Haematological Stem Cell Transplant Research Group, Co-Director Stem Cell Cryopreservation and Manipulation Unit, School of Clinical and Laboratory Sciences, Haematological Sciences University Department of Haematology, University of Newcastle,Newcastle upon Tyne, UK .
The Haematological Sciences section of the School of Clinical and Laboratory Sciences is also the Northern Regional Transplant Centre for Leukaemia and Lymphoma with a population base of 3.0 million. Information on all transplants is centralised and data registered through the BMT team (Prof. S J Proctor, Dr G Jackson, Director of the BMT Unit and Consultant in Haematology and Dr P Taylor, Clinical Specialist and Data Manager. The research of the Unit is supported by grants from the European Commission , Leukaemia Research Fund, and the Tyneside Leukaemia Research Fund.

Research Group and Collaborators include
Dr Peter Middleton Lecturer in Molecular Haematology -   p.g.middleton@ncl.ac.uk
Dr Xaio.N.Wang Senior Research Associate -   x.n.wang@ncl.ac.uk
Dr Hannah Cullup Research Associate -  hannah.cullup@ncl.ac.uk
Mark Jarvis PhD Candidate -  mark.jarvis@ncl.ac.uk
Dr Gail Stark Research Registrar -  g.stark@ncl.ac.uk
Dr Matthew Collin LRF Clinical Research Fellow -  matthew.collin@ncl.ac.uk
Dr Scott Marshall- Research Registrar -  scott.marshall@ncl.ac.uk
Gary Cavanagh PhD candidate-Head Histocompatibility and Immunogenetics section NBA Newcastle

For further information about the University of Newcastle Faculties and School visit the web
site -  www.ncl.ac.uk

Related EC funded project EUROBANK -  www.eurotransplantbank.org

Related Publications

Middleton PG, Taylor PRA, Jackson G, Proctor SJ, Dickinson AM. Cytokine gene polymorphism's associating with severe acute graft vs host disease in HLA identical sibling transplants. Blood (1998) 92(10):3943-3948.

Cavet J, Middleton PG, Segall M, Noreen H, Davies SM, Dickinson AM. Recipient tumour necrosis factor a and interleukin 10 gene polymorphisms associated with early mortality and acute graft versus host disease severity in HLA matched sibling bone marrow transplants. Blood (1999) 94(11):3941-3946.

Cavet J, Dickinson AM, Cullup H, Middleton PG. Interferon-gamma and Interleukin-six gene polymorphisms associate with graft versus host disease in HLA-matched sibling bone marrow transplantation. Blood (2001) 98 (5):1594-1600.

Middleton PG, Cullup H, Cavet J, Jackson GH, Taylor PRA, Dickinson AM. Oestrogen receptor a gene polymorphismn associates with occurrence of graft versus host disease and reduced survival in HLA-matched sib-allo BMT. Bone Marrow Transplant (2003), 32:41-47.

Jarvis M, Marzolini M, Wang XN, Jackson G, Sviland L, Dickinson AM. Heat shock protein 70: Correlation of expression with degree of graft-versus-host response and clinical GvHD. Transplantation (2003) (In Press).

Cullup H, Dickinson AM, Cavet J, Jackson GH, Middleton PG. Polymorphisms of IL-1alpha constitute independent risk factors for chronic graft versus host disease following allogeneic bone marrow transplantation. Br J Haematol (2003) (In Press).

Stark GL, Dickinson AM, Jackson GH, Taylor PRA, Proctor SJ, Middleton PG. Tumour necrosis factor receptor type II 196M/R genotype correlates with circulating soluble receptor levels in normal subjects and with graft-versus-host disease after sibling allogeneic bone marrow transplantation. Transplantation: (2003) (In Press).

Dickinson AM. Non-HLA Immunogenetics in transplantation. Pathologie et Biologie (2003) (In Press).

Dickinson AM, Wang XN, Sviland L, Vyth-Dreese FA, Jackson GH, Schumacher TN, Haanen JBAG, Mutis T, Goulmy E. In situ dissection of the graft-versus-host activities of cytotoxic T cells for minor histocompatibility antigens. Nature Med (2002) 8(4):410-414.

Hromadniková I, Vavrincová P, Cermáková M, Stechová K, Zikan J, Fialová M, Houbova B, Dickinson AM, Vavrinec J. Skin explant model assay - a tool for detection of autoaggression in patients with rheumatoid arthritis. Czech Rheumatology (1999) 7(4):166-174.

Wang XN, Lange C, Schulz U, Sviland L, Eissner G, Oliver KM, Jackson GH, Holler E, Dickinson AM. IL-10 modulation of alloreactivity and graft versus host reactions Transplantation (2002), 74(6):772-778.

Sviland L, Hromadníková I, Sedlácek P, Cermáková M, Stechová K, Holler E, Eissner G, Schultz U, Kolb HJ, Jackson GH, Wang XN, Dickinson AM. Histological correlation between different centers using the skin explant model to predict graft-versus-host disease following bone marrow transplantation. Hum Immunol (2001), 62(11):1277-1281.

Dickinson AM, Cavet J, Cullup H, Wang XN, Jarvis M, Sviland L, Middleton PG. Predicting outcome in haematological stem cell transplantation. Archivum Immuniologiae et Therapiae Experimentalis (2002), 50:371-378.

Jarvis M, Marzolini M, Wang XN, Jackson G, Sviland L, Dickinson AM. Heat shock protein 70: Correlation of expression with degree of graft-versus-host response and clinical GvHD. Transplantation (In Press).

Dickinson AM, Wang XN, Sviland L. In vitro models of graft-versus-host disease: In Cord Blood Characteristics: Role in stem cell transplantation. Eds. Cohen SBA, Gluckman E, Rubinstein P, Madrigal JA. Published by Martin Dunitz (1999) (5) 97-127.

Dickinson AM. Predicting graft versus host disease in bone marrow transplants using in vitro techniques. In the European Commission Publication "Examples of Demonstration Projects in the Life Sciences Programmes-Vol. 3" Eds. Wakolbinger W , Jarvenpaa M, Le Dour O, Norstedt I, Aguilar A. (2000) 49-51.