Dr Mark W Lowdell BSc, MSc, PhD, MRCPath

Dr Mark W Lowdell is a senior lecturer in the Department of Haematology of the Royal Free & University College Medical School on the Royal Free Campus in London UK. He is Director of the BMT Research Group and Director of the Paul O'Gorman Laboratory of Cellular Therapeutics.

His interests are centred on the study of the immunology of haematopoietic stem cell transplantation incorporating immunotherapy, immune reconstitution and graft-versus-host disease.

His current research group consists:

Dr Chloe Marden – Research fellow c.marden@rfc.ucl.ac.uk

Dr Jeff Davies – MRC Clinical Research Fellow j.davies@rfc.uckl.ac.uk

Mr Akinwale Deru - Research Assistant wderu@rfc.ucl.ac.uk

Ms Elena Addison - Research Assistant e.addison@rfc.ucl.ac.uk

Ms Janet North - Research Assistant j.north@rfc.ucl.ac.uk

Ms Fiona O'Brien - Clinical Scientist Fiona O'Brien@royalfree.nhs.uk

Mr Kwok Pang - Clinical Scientist Kwok.Pang@royalfree.nhs.uk

Mr Ed Samuel - Clinical Scientist Edward.Samuel@royalfree.nhs.uk

Ms Maryam Sekhavat Clinical Scientist maryam.sekhavat@royalfree.nhs.uk

Recent Relevant Publications:

Davies JK, Koh MBC, Lowdell MW. (2004) Anti-viral immunity and T-Regulatory cell function are retained following selective alloreactive T cell depletion in both the HLA identical and mismatched settings. Biology of Blood & Marrow Transplantation – in press

Jones DT, Addison E, North JM, Lowdell MW, Hoffbrand AV, Mehta AB, Ganeshaguru K, Folarin NI, Wickremasinghe RG. (2003) Geldanamycin and Herbimycin A induce apoptotic killing of B-chronic lymphocytic leukemia cells and augment their sensitivity to cytotoxic drugs. Blood ; E-Pub

Orleans-Lindsay JK, Deru A, Craig JIO, Prentice HG, Lowdell MW. (2003) In vitro co-stimulation with anti-CD28 synergises with IL-12 in the generation of T cell immune responses to leukaemic cells; a strategy for ex-vivo generation of CTL for immunotherapy. Clin Exp Immunology ; 133:467-75.

Lowdell MW (2003) Inside Blood “Out damned spot” – ex-vivo purging revisited. Blood 102;3860-1.

Lowdell MW (2003) Natural Killer cells in haematopoietic stem cell transplantation. Transfusion Medicine; 13:399-404.

Smith L & Lowdell MW (2003) Quality issues in stem cell and immunotherapy laboratories. Transfusion Medicine; 13:417-23.

Davies JK & Lowdell MW (2003) New advances in acute GvHD prophylaxis. Transfusion Medicine ; 13:387-97.

Pamphilon DH & Lowdell MW (2003) Stem cells and immunotherapy. Transfusion Medicine ; 13:323-4.

Duarte RF, Chen FE, Lowdell MW, Potter MN, Lamana ML, Prentice HG, Madrigal AJ (2002) Functional impairment of human T-lymphocytes following PHA-induced expansion and retroviral transduction: Implications for gene therapy. Gene Therapy; 9:1359-68.

Koh MBC, Prentice HG, Corbo M, Morgan M, Cotter FE, Lowdell MW. (2002) Alloantigen specific T cell depletion in a Major Histocompatibility Complex fully-mismatched murine model provides effective graft versus host disease prophylaxis in the presence of lymphoid engraftment. Br J Haematology; 118:108-116.

Lowdell MW, Craston R, Samuel D, Wood ME, O'Neil E, Saha V, Prentice HG. (2002) Evidence that continued remission in patients treated for acute leukaemia is dependent upon autologous natural killer cells. Br J Haematology; 117:821-827.

Tiwari A, Hamilton G, Seifalian AM, Lowdell MW, O'Neill E. (2002) Regarding “Isolation of endothelial cells and their progenitor cells from human peripheral blood” . Journal of Vascular Surgery; 35:827.

Orleans-Lindsay J, Barber LD, Prentice HG, Lowdell MW. (2001) Acute myeloid leukaemia cells secrete soluble factors that inhibit T and NK cell proliferation but not cytolytic function - implications for the adoptive immunotherapy of leukaemia. Clin Exp Immunology; 126:403-411.

Jones DT, Ganeshaguru K, Virchis AE, Lowdell MW, Mehta AB, Prentice HG, Hoffbrand AV, Wickremasinghe RG. (2001) Caspase 8 activation independent of FAS (CD95/APO-1)-signalling may mediate killing of B-chronic lymphocytic leukaemia cells by cytotoxic drugs or g radiation. Blood; 98:2800-7.

Borras FE, Matthews NC, Lowdell MW, Navarrete CV (2001) Identification of both myeloid CD1c+ and lymphoid CD11c- dendritic cell subsets in cord blood. Br J Haematology; 113:925-31.

Hennessy B, North J, Deru A, Llewellyn-Smith N, Lowdell MW. (2001) The use of Leu3b for the accurate determination of CD4 subsets by measurement of intracellular cytokines. Cytometry; 44:148-52

Plunkett FJ, Soares MV, Annels N, Hislop A, Ivory K, Lowdell M, Salmon M, Rickinson A, Akbar AN (2001) The flow cytometric analysis of telomere length in antigen-specific CD8(+) T cells during acute Epstein-Barr virus infection. Blood; 97:700-7.